Jesus Saavedra

BIOMedicine degree: Autónoma University of Madrid, 1990. Specialist in Pediatrics at 12 de Octubre University Hospital, Madrid, 1992-1995. Subespeciality: Infectious Diseases. Research Fellow at UT Southwestern Medical Center in Dallas. 1996-1997. Clinical Fellow in Pediatric Infectious Disease at UT Southwestern Medical Center in Dallas. 1999-2002. Doctoral thesis presented on January 2007 at the School of Medicine of the Complutense University of Madrid: “Latency and HIV” Attending physician in Pediatrics at Fuenlabrada Hospital, Madrid, 2003-2007. Attending physician in Pediatrics at Gregorio Marañón Hospital in Madrid, in the Infectious Disease Unit, since 2007. Assistant Professor in Pediatrics, Complutense University, Madrid, since 2012. Investigator and co-investigator in multiple projects and clinical trials, including HIV infection, vaccines, viral respiratory infections, tuberculosis, Group A Streptococcus and osteoarticular infections. Actively working on antibiotic stewardship projects. Collaborator in the Ranin-Kids Network supported by PENTA. Co-leader of the Spanish ID Networks RioPed and Peisga for the study of osteoarticular infection and invasive GAS disease, respectively. Author and coauthor of several book chapters and multiple manuscripts. Chair of the Bone and joint infection ESPID Guidelines-2017. Member of the ESPID board from 2013-2016. Co-organizer of the 35th ESPID Conference in Madrid, Spain (2017). Co-organizer of an annual Healthcare-associated infection in children course in collaboration with the 12 Octubre Hospital in Madrid (4 editions).

Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2

Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) is a severe disease especially develop in children and adolescents, most of the time temporally associated with SARS-CoV-2 acute infection. After becoming infected with SARS-CoV-2, the majority of children and adolescents did not develop symptomatology, or this is very mild. However, in certain circumstances the acute infection can become very grave. Furthermore, soon after the beginning of the pandemia, pediatrician started to diagnose a severe syndrome in children presented with fever, hypotension, myocardial dysfunction, gastrointestinal symptoms and some clinical characteristics of Kawasaki’s disease (KD), and that seemed to appear days or weeks after the acute infection with SARS-CoV-2. Anti-inflammatory therapy, especially with IV immunoglobulin and steroids, along with medical support and symptomatic treatment as need (inotropics, antibiotics, oxygen supplementation, intubation) was implemented since the syndrome was in many ways similar to diseases thought to be caused by superantigen production (KD, toxic shock syndrome, myocarditis).

In this lecture we will talk about the pathophysiology, the clinical characteristics, the most appropriate diagnostic tools and therapy of PIMS-TS. There will be clinical cases to better illustrate the lecture and make participation more feasible. Finally, the Spanish Consensus Document for the management of PIMS-TS will be commented.

All session
by Jesus Saavedra

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