Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2
Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) is a severe disease especially develop in children and adolescents, most of the time temporally associated with SARS-CoV-2 acute infection. After becoming infected with SARS-CoV-2, the majority of children and adolescents did not develop symptomatology, or this is very mild. However, in certain circumstances the acute infection can become very grave. Furthermore, soon after the beginning of the pandemia, pediatrician started to diagnose a severe syndrome in children presented with fever, hypotension, myocardial dysfunction, gastrointestinal symptoms and some clinical characteristics of Kawasaki’s disease (KD), and that seemed to appear days or weeks after the acute infection with SARS-CoV-2. Anti-inflammatory therapy, especially with IV immunoglobulin and steroids, along with medical support and symptomatic treatment as need (inotropics, antibiotics, oxygen supplementation, intubation) was implemented since the syndrome was in many ways similar to diseases thought to be caused by superantigen production (KD, toxic shock syndrome, myocarditis).
In this lecture we will talk about the pathophysiology, the clinical characteristics, the most appropriate diagnostic tools and therapy of PIMS-TS. There will be clinical cases to better illustrate the lecture and make participation more feasible. Finally, the Spanish Consensus Document for the management of PIMS-TS will be commented.